The San Francisco 49ers (1-1) are expected to win, but by less than a touchdown (25-22 according to our computer prediction), when they play the Los Angeles Rams (0-2) at SoFi Stadium on Sunday, Sept. 22 at 4:25 p.m. ET.
49ers vs. Rams predictions
- Pick ATS: Rams (+6.5)
- Pick OU: Over (43.5)
- Prediction:
49ers 25 – Rams 22
49ers vs. Rams odds and lines
National Football League odds courtesy of BetMGM. Odds updated Saturday at 5:38 p.m. ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread favorite: 49ers (-6.5)
- Moneyline: 49ers (-300), Rams (+240)
- Total: 43.5 points
49ers betting stats
- San Francisco hasn won once against the spread this season.
- San Francisco has had one game (of two) hit the over this season.
Rams betting stats
- Los Angeles has not won a game against the spread this season.
- One of Los Angeles’ two games has hit the over.
- The Rams lost the only game they’ve played as the underdog this season.
49ers vs. Rams game info
- Game day: Sunday, September 22, 2024
- Game time: 4:25 p.m. ET
- TV channel: FOX
- Location: Inglewood, California
- Stadium: SoFi Stadium
- TV channel: FOX
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