The San Francisco 49ers (2-2) visit Bank of America Stadium to take on the Carolina Panthers (1-3) on Oct. 9. Kickoff is scheduled for 4:05pm EDT in Charlotte.
The 49ers are betting favorites in Week 5, with the spread sitting at -6.5 (-110).
The 49ers vs. Panthers Over/Under is 39.5 total points for the game.
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49ers vs. Panthers Prediction for Week 5
Based on recent trends, the winning team model predicts the 49ers will win this Week 5 game with 74.5% confidence.
Based on recent against-the-spread trends, the model predicts the 49ers will cover the spread this Week 5 with 62.0% confidence.
Both predictions factor in up-to-date player injuries for both the 49ers and Panthers, plus offensive & defensive matchups, recent games and key player performances this season.
Best 49ers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for 49ers players for Week 5, looking at profitable historical betting trends:
- Jimmy Garoppolo has hit the Completions Under in 12 of his last 15 games (+8.50 Units / 43% ROI)
- Deebo Samuel has hit the Receptions Under in 14 of his last 19 games (+8.00 Units / 29% ROI)
- George Kittle has hit the Receptions Under in 11 of his last 15 games (+6.05 Units / 27% ROI)
- George Kittle has hit the Receiving Yards Under in 10 of his last 15 games (+3.95 Units / 21% ROI)
- Ray-Ray McCloud has hit the Receiving Yards Over in 5 of his last 6 games (+3.80 Units / 55% ROI)
Best Panthers Player Prop Best Bets Today
And here are some top NFL player prop bets for Panthers players for Week 5, looking at profitable historical betting trends:
- D.J. Moore has hit the Receiving Yards Under in 13 of his last 16 games (+9.35 Units / 46% ROI)
- Robby Anderson has hit the Receiving Yards Under in 12 of his last 16 games (+7.00 Units / 35% ROI)
- Laviska Shenault Jr. has hit the Receptions Over in his last 6 games at home (+6.50 Units / 92% ROI)
- Sam Darnold has hit the TD Passes Under in his last 6 games (+6.30 Units / 70% ROI)
- Sam Darnold has hit the Passing Yards Under in his last 6 games (+6.00 Units / 82% ROI)
49ers Betting Trends: ATS, Moneyline, Over/Under
- The San Francisco 49ers have hit the Game Total Under in 11 of their last 12 games (+9.90 Units / 75% ROI)
- The San Francisco 49ers have hit the 1H Game Total Under in 9 of their last 10 games (+9.00 Units / 81% ROI)
- The San Francisco 49ers have covered the Spread in 12 of their last 16 games (+7.75 Units / 44% ROI)
- The San Francisco 49ers have hit the 1Q Game Total Under in 10 of their last 12 games (+7.70 Units / 56% ROI)
- The San Francisco 49ers have covered the 1H Spread in 12 of their last 16 games (+7.70 Units / 45% ROI)
Panthers Betting Trends: ATS, Moneyline, Over/Under
- The Carolina Panthers have hit the 1Q Moneyline in 7 of their last 17 games (+7.25 Units / 38% ROI)
- The Carolina Panthers have scored first in 9 of their last 13 games (+6.70 Units / 46% ROI)
- The Carolina Panthers have hit the Team Total Under in 10 of their last 15 games (+5.55 Units / 33% ROI)
- The Carolina Panthers have hit the 1Q Game Total Under in 10 of their last 15 games (+5.30 Units / 30% ROI)
- The Carolina Panthers have hit the 2H Game Total Over in their last 5 games (+5.00 Units / 90% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers have gone 2-2 (-0.2 Units / -4.55% ROI).
- 49ers are 2-2 when betting on the Moneyline for -1.85 Units / -20.67% ROI
- 49ers are 0-4 when betting the Over for -4.4 Units / -100% ROI
- 49ers are 4-0 when betting the Under for +4 Units / ROI
Panthers Against the Spread (ATS) Record
Against the spread this NFL season, the Panthers have gone 1-3 (-2.3 Units / -52.27% ROI).
- Panthers are 1-3 when betting on the Moneyline for -2.45 Units / -53.85% ROI
- Panthers are 1-3 when betting the Over for -2.35 Units / -52.81% ROI
- Panthers are 3-1 when betting the Under for +1.9 Units / 43.68% ROI
San Francisco 49ers: Keys to the Game vs. the Carolina Panthers
The 49ers are 9-0 (1.000) when not throwing an interception since the 2021 season — tied for best in NFL. The Panthers have intercepted 12 passes since the 2021 season — tied for second-fewest in NFL.
The 49ers are undefeated (8-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .536.
The 49ers were 4-2 (.667) vs top 10 pass offenses last season — tied for 5th-best in NFL; League Avg: .365.
The 49ers are 9-1 (.900) when allowing less than 100 rushing yards since the 2021 season — best in NFL; League Avg: .654.
Carolina Panthers: Keys to the Game vs. the San Francisco 49ers
The Panthers are 2-11 (.154) when making less than 7 explosive plays since the 2021 season — 3rd-worst in NFL; League Avg: .413.
The Panthers are winless (0-7) since Week 11 — worst in NFL; League Avg: .500.