The NFC's top-two teams meet in a mammoth clash headlining the NFL's Week 13 slate as the Philadelphia Eagles host the San Francisco 49ers, and we offer our best 49ers vs. Eagles prediction based on the best NFL odds at our best sportsbooks.
San Francisco is one of three 8-3 teams in the NFC and one of five in the NFL riding a three-game winning streak or better entering this week. The 49ers beat the Seattle Seahawks by 18 on Thanksgiving for their 10th consecutive division win, the longest active streak in the league.
The Philadelphia Eagles became the first team to lose a Super Bowl and start 9-1 or better since the Buffalo Bills did it in 1991. They now sit 10-1 thanks to Jalen Hurts' first career five-touchdown game.
To accompany our 49ers vs. Eagles NFL player props, here is our best 49ers vs. Eagles prediction and our NFL picks (odds via our best NFL betting sites; pick confidence based on a 1-to-5-star scale).
For more action on this game, don't miss our Jalen Hurts NFL player props, Brock Purdy props, Christian McCaffrey props, and our A.J. Brown NFL player props.
49ers vs. Eagles prediction
This can potentially kick-off as a historical game from a point-spread perspective. Per BetMGM's John Ewing, only three teams since 2004 with odds of 10-1 or better have been home underdogs. However, in two of those instances, the underdog had backup quarterbacks starting since the games were played in Week 17.
Thus, our best sports betting apps are tipping their hand that they feel San Francisco is the better team and will expose Philadelphia amid a torrid start. But instead of backing the 49ers for the full game, we are targeting the first-half moneyline based on how the Eagles have started games rece ntly.
Philadelphia's five-game winning streak is tied with the Denver Broncos for the longest active streak. Still, it's largely due to out-scoring opponents 79-30 in the second half and overtime of the last four games, as it has trailed at the half in four straight (and is 5-0 in games it has trailed at halftime this season).
In the first 30 minutes of all games this season, Hurts ranks 15th in QBR, is tied for 17th in passing touchdowns, and is 19th in yards per attempt. However, in the second halves of all games (and overtime periods), Hurts improves to third in QBR, tied for second in passing touchdowns, and fourth in yards per attempt.
While the Eagles won without right tackle Lane Johnson last week, they are just 14-22 when he does not suit up, and his injury will be something to monitor this week. Conversely, San Francisco is the healthiest it has been all season and has the NFL's second-be st point differential (+140). Its three-game hiccup from Weeks 6-8 was heavily tied to injuries to Deebo Samuel and Trent Williams, but with them back in the fold, Brock Purdy has completed 75.3% of his passes with a 7-1 TD-INT ratio over the last three games.
This is a three-star play, as the 49ers defense allows a league-best 9.5% of opponents' possessions to end in a touchdown in road games, per Sharp Football Analysis. We would make this a more confident four-star play if the weather forecast improved, as Purdy's worst game this season in terms of completion percentage, yards per attempt, and QBR was on the road in a soaking rain at the Cleveland Browns.
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49ers vs. Eagles best odds
| DraftKings | FanDuel | BetMGM | Caesars | bet365 |
|---|---|---|---|---|
| -130 | -128 | N/A | -125 | -125 |
49ers first-half moneyline backers will find the best value at either Caesars or bet365, with their odds climbing as high as -130 at DraftKings. Caesars and DraftKings offer the same -0.5 point spread while FanDuel is slightly higher at -1.5, but we prefer the added insurance at a slightly higher price with the moneyline odds, as our bet would be voided and returned if the 49ers and Eagles are tied at halftime.
We are also not looking to fade Philadelphia for the full-game moneyline, as it is 11-0 straight up in its last 11 games at Lincoln Financial Field against teams with a winning record.
49ers vs. Eagles odds
49ers vs. Eagles odds analysis
There is a wide range regarding the point spread among the best sports betting apps for this matchup. BetMGM is the only shop offering a line as low as San Francisco -1.5 (thoug h it charges -130 in juice to back the favorite), while DraftKings is the highest on the 49ers at -3 (-102). All other competitors are slightly under a field goal at -2.5, though FanDuel did hit -3 on Tuesday before lowering back down to -2.5. The Eagles are a popular underdog, attracting 80% of the early point spread wagers.
Caesars is the only sportsbook offering a total of 45.5, while the rest of the best sports betting sites are a full point higher at 46.5. DraftKings opened at 46 on Sunday night but has had its total bounce between 46.5 and 47 multiple times early in the week. There is dead-even, two-way action on the total across all of our best sportsbooks, while the Eagles have the longest active Over streak (four games) in the league.
49ers vs. Eagles game info
- When: Sunday, Dec. 3 at 4:25 p.m. ET
- Where: Lincoln Financial Field, Philadelphia, PA
- How to watch : FOX
- Weather: 54 degrees, 52% chance of precipitation, wind 9 mph NNE
49ers-Eagles prediction made 11/29/2023 at 4:01 p.m. ET
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