The San Francisco 49ers (5-4) visit Estadio Azteca to take on the Arizona Cardinals (4-6) on Nov. 21. Kickoff is scheduled for 8:15pm EST in Mexico City for Monday Night Football.
The 49ers are betting favorites in Week 11, with the spread sitting at -7.5 (-115).
The 49ers vs. Cardinals Over/Under is 43.5 total points for the game.
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49ers vs. Cardinals Prediction for Week 11
Based on recent trends, the winning team model predicts the 49ers will win this Week 11 game with 72.8% confidence.
Based on recent against-the-spread trends, the model predicts the Cardinals will cover the spread this Week 11 with 54.0% confidence.
Both predictions factor in up-to-date player injuries for both the 49ers and Cardinals, plus offensive & defensive matchups, recent games and key player performances this season.
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Best 49ers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for 49ers players for Week 11, looking at profitable historical betting trends:
- Deebo Samuel has hit the Receptions Under in 14 of his last 19 games (+7.40 Units / 27% ROI)
- Jimmy Garoppolo has hit the Completions Under in 12 of his last 17 games (+5.80 Units / 26% ROI)
- George Kittle has hit the Receptions Under in 13 of his last 19 games (+5.45 Units / 20% ROI)
- Brandon Aiyuk has hit the Receiving Yards Over in 13 of his last 21 games (+4.10 Units / 18% ROI)
- Tajae Sharpe has hit the Receiving Yards Under in his last 4 games (+4.00 Units / 80% ROI)
Best Cardinals Player Prop Best Bets Today
And here are some top NFL player prop bets for Cardinals players for Week 11, looking at profitable historical betting trends:
- Marquise Brown has hit the Receptions Over in 9 of his last 13 games (+5.40 Units / 38% ROI)
- A.J. Green has hit the Receptions Under in 8 of his last 10 games (+5.25 Units / 37% ROI)
- Kyler Murray has hit the Passing Yards Under in 11 of his last 16 games (+4.85 Units / 24% ROI)
- Robby Anderson has hit the Receiving Yards Under in 8 of his last 11 games (+4.25 Units / 31% ROI)
- Zach Ertz has hit the Receptions Over in 11 of his last 17 games (+4.20 Units / 21% ROI)
49ers Best Bets for Week 11:
- The San Francisco 49ers have hit the Game Total Under in 13 of their last 17 games (+8.60 Units / 46% ROI)
- The San Francisco 49ers have covered the Spread in 14 of their last 21 games (+6.45 Units / 28% ROI)
- The San Francisco 49ers have hit the 3Q Game Total Under in 9 of their last 12 games (+5.50 Units / 40% ROI)
- The San Francisco 49ers have covered the 2Q Spread in 6 of their last 7 away games (+5.05 Units / 65% ROI)
- The San Francisco 49ers have hit the 1H Game Total Over in their last 5 games (+5.00 Units / 90% ROI)
Cardinals Best Bets for Week 11:
- The Arizona Cardinals have hit the 2H Game Total Over in 13 of their last 17 games (+8.35 Units / 44% ROI)
- The Arizona Cardinals have hit the 3Q Moneyline in 8 of their last 14 games (+3.70 Units / 24% ROI)
- The Arizona Cardinals have hit the Team Total Under in 6 of their last 8 games at home (+3.65 Units / 41% ROI)
- The Arizona Cardinals have covered the 2Q Spread in 4 of their last 5 games at home (+3.20 Units / 59% ROI)
- The Arizona Cardinals have hit the 3Q Game Total Over in 4 of their last 8 games at home (+3.00 Units / 34% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers have gone 4-5 (-1.5 Units / -15.23% ROI).
- 49ers are 5-4 when betting on the Moneyline for -1.75 Units / -9.16% ROI
- 49ers are 3-6 when betting the Over for -3.6 Units / -36.36% ROI
- 49ers are 6-3 when betting the Under for +2.7 Units / ROI
Cardinals Against the Spread (ATS) Record
Against the spread this NFL season, the Cardinals have gone 5-5 (-0.55 Units / -4.98% ROI).
- Cardinals are 4-6 when betting on the Moneyline for -1.15 Units / -10.22% ROI
- Cardinals are 6-4 when betting the Over for +1.6 Units / 14.55% ROI
- Cardinals are 4-6 when betting the Under for -2.6 Units / -23.64% ROI
San Francisco 49ers: Keys to the Game vs. the Arizona Cardinals
The 49ers are undefeated (10-0) when the opposing team converts less than 55% of its red zone chances into touchdowns since the 2021 season — best in NFL; League Avg: .539.
The 49ers are 2-1 (.667) when getting more than 3 points since the 2021 season — tied for best in NFL; League Avg: .314.
The 49ers are 12-1 (.923) when allowing less than 100 rushing yards since the 2021 season — best in NFL; League Avg: .661.
The 49ers are undefeated (8-0) when not committing any turnovers since the 2021 season — tied for best in NFL; League Avg: .734.
Arizona Cardinals: Keys to the Game vs. the San Francisco 49ers
The Cardinals are 1-4 (.200) at home this season — 2nd-worst in NFL; League Avg: .559.
The Cardinals are winless (0-4) when allowing 3 or more sacks this season — tied for worst in NFL; League Avg: .378.