The San Francisco 49ers play in their second consecutive primetime game as they head to Mexico City to face the Arizona Cardinals. Read on for our 49ers-Cardinals picks.
In an effort to grow the game globally, the NFL has added games in Mexico in addition to their annual London games. This is the fifth iteration of games in Azteca Stadium, and it is a pivotal NFC West battle. Just 1.5 games separate the 5-4 49ers and 4-6 Cardinals, but each team is very much alive for a division title, as the 6-4 Seattle Seahawks have not run away with things.
Arizona swept the season series against San Francisco last year by a combined score of 48-27. The Cardinals have also won three of the previous four meetings dating back to the start of the 2020 season.
Here are our 49ers-Cardinals NFL picks for Week 11 (odds via PointsBet, DraftKings Sportsbook; pick confidence based on a 1-to-5-star scale).