It'll be a bit of a different setting for this week's Monday Night Football game, as the San Francisco 49ers and Arizona Cardinals will clash at Estadio Azteca in Mexico City at 8:15PM ET on November 21.
Find out how we think this one will play out in our 49ers vs. Cardinals betting preview.
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49ers vs. Cardinals Computer Picks
- No edge on either team to cover the 8-point spread
- 78% chance the 49ers win on the moneyline
- 56% chance 49ers-Cardinals goes Over 43.5
For the best NFL computer picks, check out our 49ers vs. Cardinals data predictions. They are constantly updating based on hundreds of different data points.