The San Francisco 49ers (5-0) visit Cleveland Browns Stadium to take on the Cleveland Browns (2-2) on Oct. 15. Kickoff is scheduled for 1:00pm EDT in Cleveland.
The 49ers are betting favorites in this Week 6 matchup, with the spread sitting at -5.5 (-110).
The 49ers vs. Browns Over/Under is 37.5 total points for the game.
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49ers vs. Browns Prediction
Based on recent trends, the winning team model predicts the 49ers will win this Week 6 game with 74.0% confidence.
Based on recent against-the-spread trends, the model predicts the Browns will cover the spread with 54.0% confidence.
Both predictions factor in up-to-date player injuries for both the 49ers and Browns, plus offensive & defensive matchups, recent games and key player performances this season.
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Best 49ers Player Prop Bets Today
We’ve highlighted some favorite NFL player prop bets for 49ers players this Week 6 game, looking at profitable historical betting trends:
- George Kittle has hit the Longest Reception Over in 13 of his last 16 games (+9.55 Units / 51% ROI)
- Jauan Jennings has hit the Receiving Yards Over in 11 of his last 14 games (+7.70 Units / 49% ROI)
- Christian McCaffrey has hit the Longest Rush Over in his last 7 away games (+7.00 Units / 89% ROI)
- Christian McCaffrey has hit the Carries Under in 8 of his last 9 games (+6.95 Units / 57% ROI)
- Deebo Samuel has hit the Longest Reception Under in 7 of his last 8 games (+5.40 Units / 51% ROI)
Best Browns Player Prop Best Bets Today
And here are some top NFL player prop bets for Browns players for this matchup, looking at profitable historical betting trends:
- Nick Chubb has hit the Longest Rush Over in 12 of his last 15 games (+8.30 Units / 47% ROI)
- Donovan Peoples-Jones has hit the Longest Reception Over in 10 of his last 12 games (+7.65 Units / 55% ROI)
- Nick Chubb has hit the Rushing Yards Over in 12 of his last 17 games (+6.25 Units / 32% ROI)
- Nick Chubb has hit the Receptions Under in his last 6 games at home (+6.00 Units / 59% ROI)
- Amari Cooper has hit the Receiving Yards Over in 7 of his last 8 games at home (+5.95 Units / 66% ROI)
49ers Best Bets:
- The San Francisco 49ers have hit the 4Q Moneyline in 13 of their last 20 games (+9.45 Units / 27% ROI)
- The San Francisco 49ers have hit the 2Q Game Total Over in 15 of their last 20 games (+9.40 Units / 42% ROI)
- The San Francisco 49ers have covered the 2H Spread in 14 of their last 20 games (+8.70 Units / 40% ROI)
- The San Francisco 49ers have hit the 2H Moneyline in 15 of their last 20 games (+8.55 Units / 20% ROI)
- The San Francisco 49ers have hit the 1H Game Total Over in 8 of their last 9 away games (+6.95 Units / 71% ROI)
Browns Best Bets:
- The Cleveland Browns have scored first in 11 of their last 16 games (+5.25 Units / 28% ROI)
- The Cleveland Browns have hit the 4Q Game Total Under in 6 of their last 8 games at home (+3.70 Units / 39% ROI)
- The Cleveland Browns have hit the 3Q Game Total Over in 9 of their last 16 games (+3.50 Units / 19% ROI)
- The Cleveland Browns have covered the 2H Spread in 6 of their last 9 games at home (+2.45 Units / 24% ROI)
- The Cleveland Browns have covered the 2Q Spread in 5 of their last 8 games at home (+1.70 Units / 19% ROI)
49ers Against the Spread (ATS) Record
Against the spread this NFL season, the 49ers went 4-0 (+4 Units / 73.39% ROI).
- 49ers are 5-0 when betting on the Moneyline for +5 Units / 22.68% ROI
- 49ers are 3-2 when betting the Over for +0.8 Units / 14.55% ROI
- 49ers are 2-3 when betting the Under for -1.3 Units / ROI
Browns Against the Spread (ATS) Record
Against the spread this NFL season, the Browns went 2-2 (-0.2 Units / -4.55% ROI).
- Browns are 2-2 when betting on the Moneyline for -0.4 Units / -7.55% ROI
- Browns are 1-3 when betting the Over for -2.3 Units / -52.27% ROI
- Browns are 3-1 when betting the Under for +1.9 Units / 43.18% ROI
San Francisco 49ers: Keys to the Game vs. the Cleveland Browns
The 49ers are undefeated (5-0) this season — tied for best in NFL; League Avg: .500.
The 49ers are 15-0 (1.000) when not throwing an interception since the 2022 season — tied for best in NFL. The Browns have intercepted 12 passes since the 2022 season — tied for fifth-fewest in NFL.
The 49ers are 8-3 (.727) vs top 10 offenses since the 2021 season — best in NFL; League Avg: .351.
The 49ers are 10-3 (.769) vs top 10 pass offenses since the 2021 season — 2nd-best in NFL; League Avg: .364.
Cleveland Browns: Keys to the Game vs. the San Francisco 49ers
The Browns are 4-9 (.308) when throwing at least 1 interception since the 2022 season — ninth-worst in NFL. The 49ers have intercepted 28 passes since the 2022 season — most in NFL.
The Browns are winless (0-5) after a road win since the 2021 season — tied for worst in NFL; League Avg: .544.
The Browns are winless (0-3) when allowing 250 or more passing yards since the 2022 season — worst in NFL; League Avg: .455.
The Browns are winless (0-5) when allowing 300 or more passing yards since the 2021 season — worst in NFL; League Avg: .425.