49ers vs. Browns best bets, picks and props | Week 6

The San Francisco 49ers (5-0) visit the Cleveland Browns (2-2) on Sunday, October 15, 2023 at Cleveland Browns Stadium and will aim to continue a five-game winning streak. Check out the best bets.

How to watch 49ers vs. Browns

  • When: Sunday, October 15, 2023 at 1:00 PM ET
  • Where: Cleveland Browns Stadium in Cleveland, Ohio
  • TV Info: FOX
  • Live Stream: Watch on Fubo!

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Best against the spread pick

  • Pick ATS: San Francisco (-9.5)
  • San Francisco has gone 4-0-1 ATS this season.
  • The 49ers have been favored by 9.5 points or more two times this season and have covered the spread in all of them.
  • Cleveland has two wins versus the spread in four games this season.

Best over/under pick

  • The Browns and their opponents have scored more than 36 combined points once this season.
  • These two teams score a combined 52.4 points per game, 16.4 more points than this matchup’s over/under.
  • Combined, these teams surrender 28.6 points per game, 7.4 fewer points than this matchup’s over/under.

Best moneyline bet

  • Moneyline: 49ers (-500), Browns (+375)
  • Prediction:
    San Francisco 26 – Cleveland 15
  • The 49ers have an implied moneyline win probability of 83.3% in this matchup.
  • San Francisco has won all five of the games it has been favored on the moneyline this season.
  • The 49ers have played as a moneyline favorite of -500 or shorter in just two games this season, and they won both.
  • Cleveland lost the only game it has played as the underdog this season.
  • The Browns have not been a bigger underdog this season than the +375 moneyline set for this game.

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