The Cleveland Browns and San Francisco 49ers are scheduled to collide on Sunday, Oct. 15. Kickoff is set for 1:00 p.m. ET at Cleveland Browns Stadium in Cleveland.
The 49ers are a 4.5-point favorite in Week 6 NFL odds.
49ers vs. Browns Weather: Temperature
The predicted daytime high is 57 degrees, while the nighttime low is 52 degrees.