![2025 Arizona Cardinals NFL Super Bowl and Playoff Odds 2025 Arizona Cardinals NFL Super Bowl and Playoff Odds](https://sportsbookwire.usatoday.com/wp-content/uploads/sites/16/2024/07/22243523.jpg)
The Arizona Cardinals currently sport +10000 odds to win the Super Bowl.
The Cardinals had a 4-13 record a year ago, and they failed to qualify for the playoffs. Their offense put up 19.4 points per game (24th in the league), while their defense conceded 26.8 (31st).
The Cardinals visit the Buffalo Bills in Week 1, with kickoff at 1:00 PM ET on Sunday, September 8. Buffalo is a 7-point favorite, with the point total set at 48.
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