2023 NCAA Tournament: Pittsburgh vs. Iowa State prediction, odds, line, spread picks for Friday's game from proven model

The sixth-seeded Iowa State Cyclones are looking for yet another deep NCAA Tournament run when they face the 11th-seeded Pittsburgh Panthers in Midwest Region first-round action on Friday. The Cyclones (19-13, 9-9 Big 12), who have a 14-7 all-time record in the first round of the NCAA Tournament, reached the Sweet 16 last season before falling to Miami. The Panthers (23-11, 14-6 ACC), who beat Mississippi State 60-59 in Tuesday's First Four matchup, have advanced to the second round in seven of the past nine trips to the tournament. Pittsburgh last played in the tournament in 2016 when it lost in the first round to Wisconsin 47-43.
  
Read Full Article