2022 NFL Week 1 Bills vs. Rams odds: Buffalo expert reveals picks for Thursday Night Football NFL Kickoff showdown
2022 NFL Week 1 Bills vs. Rams odds: Buffalo expert reveals picks for Thursday Night Football NFL Kickoff showdown

The 2022 NFL season kicks off Sept. 8, and the reigning Super Bowl-champion Los Angeles Rams will begin their title defense with a tough test against the Buffalo Bills. The Thursday Night Football NFL Kickoff matchup at L.A.'s SoFi Stadium pits the Matt Stafford-led Rams against Josh Allen and the Bills, and it's Buffalo that's the favorite to win it all. The Bills are +600 to win the Super Bowl, according to Caesars Sportsbook, while the Rams are +1100, behind Buffalo and Tampa Bay (+750). The B ills lost to the Chiefs 42-36 in overtime in an AFC Divisional playoff game in January, and L.A. beat the Bengals in the Super Bowl 23-20 three weeks later.

Kickoff in Englewood, Calif. is set for 8:20 p.m. ET. Caesars Sportsbook lists Buffalo as a 2.5-point favorite in its latest Bills vs. Rams odds, with the Over/Under for total points scored set at 53.'

Before you make any Rams vs. Bills picks or NFL predictions of your own, you NEED to hear what NFL expert Mike Tierney has to say.

A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Tierney has covered the NFL for decades and reported from seven Super Bowls. Mike does not consider himself a pet lover. But he likes 'dogs, preferring to evaluate each game from the underdog's point of view.'

  
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