2022 NCAA Tournament Villanova vs. Kansas line, picks: Advanced computer college basketball model releases selections for Final Four matchup

Jay Wright and the Villanova Wildcats face Bill Self and the Kansas Jayhawks in a Final Four matchup in New Orleans at 6:09 p.m. ET on Saturday. Kansas is favored by four points at Caesars Sportsbook, while the Over-Under is set at 134 (see up-to-date'odds for every game this week on our college basketball odds page). Villanova guard Justin Moore (Achilles) is out for this one.'

Before making any Villanova vs. Kansas picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Villanova has been lights-out on defense in recent days. The Wildcats held Michigan and Houston to just 99 points combined, and no team has scored more than 61 points against Villanova in a 2022 NCAA Tournament game. Villanova is a top-20 team in the country in defensive efficiency, and the Wildcats are allowing only 30.1 percent shooting from 3-point range. the Wildcats are also in the top 50 of the nation in free-throw rate allowed, and Villanova forces a turnover on almost 19 percent of defensive possessions.

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