2022 NCAA Tournament Duke vs. North Carolina odds, line: College basketball expert reveals pick for Saturday's Final Four clash

The Duke Blue Devils and North Carolina Tar Heels take their storied rivalry to a new level as they meet in the NCAA Tournament for the first time when they square off in the Final Four on Saturday. The ACC adversaries split their two meetings during the regular season, with each winning on the road, but the Tar Heels own a 141-115 advantage in the all-time series. Duke (32-6), the No. 2 seed in the West Region of the 2022 NCAA Tournament, advanced by defeating Arkansas 78-69. Seeded eighth in the East Region, North Carolina (28-9) rolled past Saint Peter's 69-49 to move on.

Tip-off at the Caesars Superdome in New Orleans is set for 8:49 p.m. ET. The Blue Devils are four-point favorites in the latest Duke vs. North Carolina odds from Caesars Sportsbook, while the over-under for total points scored is 153.

Before making any North Carolina vs. Duke picks or 2022 NCAA Tournament predictions, you NEED to see what SportsLine college basketball expert Matt Severance has to say.

A well-connected writer and handicapper who has worked in the industry since 2005, Severance is on a stunning run: He is a'blistering 102-71-4 on his last 177 against-the-spread picks,'returning $2,379 for $100 bettors during that span. Anyone who has followed him is WAY UP!

  
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