It's no surprise the Bills (+300) enter the 2022 season as the AFC favorites. As the favorites to win the Super Bowl and the MVP odds leader, the Bills will be expected to take a big step up.
The Bills most likely challenger, the Chiefs (+500), have been their kryptonite in the postseason. Buffalo has lost to Kansas City in the past 2 postseasons, both in Arrowhead.'
It certainly feels like a two-team race for the top spot. But there are plenty of up-and-coming teams to challenge the Bills and Chiefs for the top spot.